Harvard Philanthropist, Jeffrey Epstein, Backs Critical Discovery for Combatting Crohns Disease: PR Newswire/New York
The Jeffrey Epstein VI Foundation has been a long standing supporter of the Crohns and Colitis Foundation of America (CCFA), one of the largest foundations of its kind dedicated to eradicating the disease. Today, approximately 700,000 Americans are diagnosed every year and many more with similar symptoms. Crohns and Colitis Disease is a chronic condition of the lower intestinal track, causing inflammation and crippling symptoms from ulcers to intestinal rupture. Not much is known about the ultimate cause of Crohns but for the first time in its history, researchers sponsored by the CCFA, have isolated key bacteria that cause the inflammation.
The research is part of CCFA's Microbiome Initiative—which identified fourteen bacterial metabolic profiles associated with irritable bowel disease. To combat these fourteen bacteria, the team have developed a line of novel inhibitor molecules to block specific bacterial metabolic pathways. The inhibitors represent the first clinical treatment for Crohns and Colitis that address the underlying cause, instead of the symptoms. And while the root cause of the illness is still obscure, there is little doubt that various bacteria cause the debilitating inflammation.
"We anticipate that in the next three to five years, we will have isolated microbial targets and develop strategies that will form the basis for new therapeutic interventions," Dr. R.Balfour Sator remarked, CCFA's Chief Medical Advisor and Midget Distinguished Professor of Medicine, Microbiology & Immunology, and Director of the UNC Multidisciplinary IBD Center.
In addition to the Microbiome Initiative, the CCFA has a Genetics Initiative a growing database of more than a hundred internationally-identified genetic markers that contribute to IBD risk. So far, seven genetic pathways that regulate immune function and, or the intestinal lining cell response to injury, have been highlighted for intensive investigation for inhibitor therapy.
The Jeffrey Epstein VI Foundation will continue to be a proud supporter of CCFA and the wide talented network of scientists around the world dedicated to combatting the devastating disease of Crohns and Colitis.
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